Cerezyme and Ceredase Compared

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Dr Gregory Grabowski of the University of Cincinatti, Ohio reported on his trial comparing Ceredase and Cerezyme at the NGF Conference in Philadelphia November 1994.

A double-blind randomised parallel trial was conducted with 30 moderate to severely affected patients. The recombinant enzyme Cerezyme differed from the placental enzyme Ceredase in only one molecular respect.

At a dose of 60 units per kilo every two weeks (the high dose), there were no statistically significant differences between improvements in haemoglobin levels, platelet counts, liver or spleen size decrease. The results are as follows:

           Haemoglobin  Platelets  Liver Size  Spleen size
Cerezyme +20% +33% -11% -35%
Ceredase +16% +26% -10% -30%

Ceredase showed higher levels of antibodies but no patient had any major reaction to either treatment. Because it is produced by a recombinant method, Cerezyme is thought to be free of infectious contaminants.

Dr Ari Zimran pointed out that although Dr Grabowski's comparative results were not statistically significant, Cerezyme did better than Ceredase under all four parameters. He therefore felt that Cerezyme was more effective, partly because it did not require such a severe filtering process as Ceredase.

Source: Gauchers News February 1995
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